How does intraarticular dexmedetomidine injection effect articular cartilage and synovium? An animal study
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چکیده
منابع مشابه
Effect of intraarticular injection of lornoxicam on the articular cartilage & synovium in rat.
BACKGROUND & OBJECTIVE Intraarticular (i.a) drug application is consider to be a new therapeutic approach for the treatment of postoperative pain after arthroscopic knee surgery without any systemic adverse effects. Lornoxicam, a nonsteroid anti-inflammatory drug is a short acting agent, and its anti-inflammatory and analgesic activity may be effective in the postoperative pain management in mi...
متن کاملIntra-articular injection of ketorolac in the rat knee joint: effect on articular cartilage and synovium.
We have investigated the effects of intra-articular (i.a.) administration of ketorolac in the rat knee joint. Thirty Sprague-Dawley rats were given 0.25 ml of a standard preparation of ketorolac trometamol (10 mg ml-1) by injection into the right knee joint and 0.25 ml of 0.9% physiological saline solution by injection into the left knee as a control. Ten rats were killed at 24 h, 10 at 48 h an...
متن کاملRepair of large animal partial-thickness cartilage defects through intraarticular injection of matrix-rejuvenated synovium-derived stem cells.
Cartilage defects have a limited ability to self-heal. Stem cell treatment is a promising approach; however, replicative senescence is a challenge to acquiring large-quantity and high-quality stem cells for cartilage regeneration. Synovium-derived stem cells (SDSCs) are a tissue-specific stem cell for cartilage regeneration. Our recent findings suggest that decellularized stem cell matrix (DSCM...
متن کاملIntra-articular injection of dexketoprofen in rat knee joint : Histopathologic assessment of cartilage & synovium
BACKGROUND & OBJECTIVES Effective pain control following outpatient surgical procedures is an important aspect of patient discharge. This study was carried out with an aim to investigate the histopathological effects of intra-articular dexketoprofen trometamol injection in knee joint on synovium and cartilage in an experimental rat model. METHODS In each of 40 rats, the right knee was designa...
متن کاملCXCL10 is upregulated in synovium and cartilage following articular fracture.
The objective of this study was to investigate the expression of the chemokine CXCL10 and its role in joint tissues following articular fracture. We hypothesized that CXCL10 is upregulated following articular fracture and contributes to cartilage degradation associated with post-traumatic arthritis (PTA). To evaluate CXCL10 expression following articular fracture, gene expression was quantified...
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ژورنال
عنوان ژورنال: BMC Anesthesiology
سال: 2020
ISSN: 1471-2253
DOI: 10.1186/s12871-020-01148-x